The −48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Aβ load in brain

Mutations in the presenilin 1 gene (PS1) account for the majority of early onset, familial, autosomal dominant forms of Alzheimer's disease (AD), whereas its role in other late onset forms of AD remains unclear. A −48 C/T polymorphism in the PS1 promoter has been associated with an increased ge...

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Detalhes bibliográficos
Main Authors: Lambert, J., Mann, D., Harris, J., Chartier-Harlin, M., Cumming, A., Coates, J., Lemmon, H., StClair, D., Iwatsubo, T., Lendon, C.
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2001
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1734889/
https://ncbi.nlm.nih.gov/pubmed/11389157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.38.6.353
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