Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree

Hereditary non-polyposis colorectal cancer (HNPCC) is the most common genetic susceptibility syndrome for colorectal cancer. HNPCC is most frequently caused by germline mutations in the DNA mismatch repair (MMR) genes MSH2 and MLH1. Recently, mutations in another MMR gene, MSH6 (also known as GTBP),...

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Dettagli Bibliografici
Autori principali: Wagner, A, Hendriks, Y, Meijers-Heijboer, E, de Leeuw, W J F, Morreau, H, Hofstra, R, Tops, C, Bik, E, Brocker-Vriends, A, van der Meer, C, Lindhout, D, Vasen, H, Breuning, M, Cornelisse, C, van Krimpen, C, Niermeijer, M, Zwinderman, A, Wijnen, J, Fodde, R
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Group 2001
Soggetti:
Short Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1734864/
https://ncbi.nlm.nih.gov/pubmed/11333868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.38.5.318
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