Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree

Hereditary non-polyposis colorectal cancer (HNPCC) is the most common genetic susceptibility syndrome for colorectal cancer. HNPCC is most frequently caused by germline mutations in the DNA mismatch repair (MMR) genes MSH2 and MLH1. Recently, mutations in another MMR gene, MSH6 (also known as GTBP),...

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Bibliografiska uppgifter
Huvudupphovsmän: Wagner, A, Hendriks, Y, Meijers-Heijboer, E, de Leeuw, W J F, Morreau, H, Hofstra, R, Tops, C, Bik, E, Brocker-Vriends, A, van der Meer, C, Lindhout, D, Vasen, H, Breuning, M, Cornelisse, C, van Krimpen, C, Niermeijer, M, Zwinderman, A, Wijnen, J, Fodde, R
Materialtyp: Artigo
Språk:Inglês
Publicerad: BMJ Group 2001
Ämnen:
Short Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1734864/
https://ncbi.nlm.nih.gov/pubmed/11333868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.38.5.318
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