Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree

Hereditary non-polyposis colorectal cancer (HNPCC) is the most common genetic susceptibility syndrome for colorectal cancer. HNPCC is most frequently caused by germline mutations in the DNA mismatch repair (MMR) genes MSH2 and MLH1. Recently, mutations in another MMR gene, MSH6 (also known as GTBP),...

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Detalhes bibliográficos
Main Authors: Wagner, A, Hendriks, Y, Meijers-Heijboer, E, de Leeuw, W J F, Morreau, H, Hofstra, R, Tops, C, Bik, E, Brocker-Vriends, A, van der Meer, C, Lindhout, D, Vasen, H, Breuning, M, Cornelisse, C, van Krimpen, C, Niermeijer, M, Zwinderman, A, Wijnen, J, Fodde, R
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2001
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1734864/
https://ncbi.nlm.nih.gov/pubmed/11333868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.38.5.318
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