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Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate.

3'-Azido-2',3'-dideoxyuridine-5'-triphosphate was found to be a potent and highly selective inhibitor of human immunodeficiency virus type 1 and simian immunodeficiency virus reverse transcriptases. The affinity of 3'-azido-2',3'-dideoxyuridine-5'-triphosphate for the reverse transcriptases was simi...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: Eriksson, B F, Chu, C K, Schinazi, R F
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1989
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172746/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2480079/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.33.10.1729
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