Targeted disruption of the galanin gene reduces the number of sensory neurons and their regenerative capacity

The neuropeptide galanin is expressed developmentally in the dorsal root ganglion (DRG) and is rapidly up-regulated 120-fold after peripheral nerve section in the adult. Here we report that adult mice carrying a loss-of-function mutation in the galanin gene have a 13% reduction in the number of cell...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Holmes, Fiona E., Mahoney, Sally, King, Von R., Bacon, Andrea, Kerr, Niall C. H., Pachnis, Vassilis, Curtis, Rory, Priestley, John V., Wynick, David
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2000
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17240/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11016970/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.210221897
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