Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes.

The specific binding of 3H-labeled gamma-aminobutyric acid ([3H]GABA) to synaptic plasma membranes from rat brains was inhibited by various quinolonecarboxylic acid derivatives (quinolones), and these inhibitions were concentration dependent. The binding of [3H]muscimol to GABAA sites was also inhib...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Tsuji, A, Sato, H, Kume, Y, Tamai, I, Okezaki, E, Nagata, O, Kato, H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC172133/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2834994/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.32.2.190
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