Penetration of SCH-39304, a new antifungal triazole, into cerebrospinal fluid of primates.

We characterized the cerebrospinal fluid (CSF) penetration and pharmacokinetics of SCH-39304 in adult rhesus monkeys receiving a single oral dose of SCH-39304 (2.0 mg/kg of body weight). The mean CSF-to-plasma area under the curve ratio was 0.63 (+/- 0.18, standard error of the mean); maximum concen...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Walsh, T J, Lester-McCully, C, Rinaldi, M G, Wallace, J E, Balis, F M, Lee, J W, Pizzo, P A, Poplack, D G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171803/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2393291/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.6.1281
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