Penetration of SCH-39304, a new antifungal triazole, into cerebrospinal fluid of primates.

We characterized the cerebrospinal fluid (CSF) penetration and pharmacokinetics of SCH-39304 in adult rhesus monkeys receiving a single oral dose of SCH-39304 (2.0 mg/kg of body weight). The mean CSF-to-plasma area under the curve ratio was 0.63 (+/- 0.18, standard error of the mean); maximum concen...

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Main Authors: Walsh, T J, Lester-McCully, C, Rinaldi, M G, Wallace, J E, Balis, F M, Lee, J W, Pizzo, P A, Poplack, D G
Formato: Artigo
Idioma:Inglês
Publicado: 1990
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC171803/
https://ncbi.nlm.nih.gov/pubmed/2393291
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