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Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors
The multidrug exporter AcrB is the inner membrane component of the AcrAB-TolC drug efflux system in Escherichia coli and is responsible for the resistance of this organism to a wide range of drugs. Here we describe the crystal structure of the trimeric AcrB in complex with a designed ankyrin-repeat...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1717020/ https://ncbi.nlm.nih.gov/pubmed/17194213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050007 |
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