Drug Export Pathway of Multidrug Exporter AcrB Revealed by DARPin Inhibitors

The multidrug exporter AcrB is the inner membrane component of the AcrAB-TolC drug efflux system in Escherichia coli and is responsible for the resistance of this organism to a wide range of drugs. Here we describe the crystal structure of the trimeric AcrB in complex with a designed ankyrin-repeat...

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Detaylı Bibliyografya
Asıl Yazarlar: Sennhauser, Gaby, Amstutz, Patrick, Briand, Christophe, Storchenegger, Otso, Grütter, Markus G
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2007
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1717020/
https://ncbi.nlm.nih.gov/pubmed/17194213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050007
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