Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus.
SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 microgram...
Guardat en:
| Publicat a: | Antimicrob Agents Chemother |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1990
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171622/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2334163/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.3.484 |
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