Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus.
SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 microgram...
Salvato in:
| Pubblicato in: | Antimicrob Agents Chemother |
|---|---|
| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology (ASM)
1990
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171622/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2334163/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.3.484 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|