Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept

Botulinum neurotoxins (BoNTs) cause muscle paralysis by selectively cleaving core components of the vesicular fusion machinery within motoneurons. Complex gangliosides initially bind into a pocket that is conserved among the seven BoNTs and tetanus neurotoxin. Productive neurotoxin uptake also requi...

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Main Authors: Rummel, Andreas, Eichner, Timo, Weil, Tanja, Karnath, Tino, Gutcaits, Aleksandrs, Mahrhold, Stefan, Sandhoff, Konrad, Proia, Richard L., Acharya, K. Ravi, Bigalke, Hans, Binz, Thomas
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1716154/
https://ncbi.nlm.nih.gov/pubmed/17185412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609713104
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