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Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept
Botulinum neurotoxins (BoNTs) cause muscle paralysis by selectively cleaving core components of the vesicular fusion machinery within motoneurons. Complex gangliosides initially bind into a pocket that is conserved among the seven BoNTs and tetanus neurotoxin. Productive neurotoxin uptake also requi...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1716154/ https://ncbi.nlm.nih.gov/pubmed/17185412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609713104 |
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