Role of protonated and neutral forms of macrolides in binding to ribosomes from gram-positive and gram-negative bacteria.
Erythromycin binds to a single site on the bacterial 50S ribosomal subunit and perturbs protein synthesis. However, erythromycin contains desosamine and thus exists in both protonated (greater than 96%) and neutral (less than 4%) forms at physiological pH because of the pKa of the dimethylamino grou...
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| Udgivet i: | Antimicrob Agents Chemother |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1990
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171609/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2159256/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.3.426 |
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