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Role of protonated and neutral forms of macrolides in binding to ribosomes from gram-positive and gram-negative bacteria.

Erythromycin binds to a single site on the bacterial 50S ribosomal subunit and perturbs protein synthesis. However, erythromycin contains desosamine and thus exists in both protonated (greater than 96%) and neutral (less than 4%) forms at physiological pH because of the pKa of the dimethylamino grou...

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Detalhes bibliográficos
Main Authors: Goldman, R C, Fesik, S W, Doran, C C
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC171609/
https://ncbi.nlm.nih.gov/pubmed/2159256
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