Role of protonated and neutral forms of macrolides in binding to ribosomes from gram-positive and gram-negative bacteria.

Erythromycin binds to a single site on the bacterial 50S ribosomal subunit and perturbs protein synthesis. However, erythromycin contains desosamine and thus exists in both protonated (greater than 96%) and neutral (less than 4%) forms at physiological pH because of the pKa of the dimethylamino grou...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Goldman, R C, Fesik, S W, Doran, C C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171609/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2159256/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.3.426
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