Significance of "extravascular" protein binding for antimicrobial pharmacodynamics in an in vitro capillary model of infection.
The effect of protein binding in an "extravascular" space on antimicrobial pharmacodynamics was studied in an in vitro capillary model of infection. Simulated 500-mg oral doses of dicloxacillin (approximately 96% bound) or cephalexin (less than 5% bound) were administered every 6 h for four doses. A...
Guardat en:
| Publicat a: | Antimicrob Agents Chemother |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1990
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171527/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2327764/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.1.98 |
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