Significance of "extravascular" protein binding for antimicrobial pharmacodynamics in an in vitro capillary model of infection.

The effect of protein binding in an "extravascular" space on antimicrobial pharmacodynamics was studied in an in vitro capillary model of infection. Simulated 500-mg oral doses of dicloxacillin (approximately 96% bound) or cephalexin (less than 5% bound) were administered every 6 h for four doses. A...

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Bibliografski detalji

Izdano u:	Antimicrob Agents Chemother
Glavni autori:	Dudley, M N, Blaser, J, Gilbert, D, Zinner, S H
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1990
Teme:	Research Article
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171527/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2327764/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.1.98
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