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Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA

We report a strategy for the reagentless transduction of DNA hybridization into a readily detectable electrochemical signal by means of a conformational change analogous to the optical molecular beacon approach. The strategy involves an electroactive, ferrocene-tagged DNA stem–loop structure that se...

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Hlavní autoři: Fan, Chunhai, Plaxco, Kevin W., Heeger, Alan J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC170884/
https://ncbi.nlm.nih.gov/pubmed/12867594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1633515100
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