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Intrinsic defect in B cells of patients with hyper-immunoglobulin M syndrome.

We challenge the theory that the CD40-CD40 ligand is the only explanation for X-linked immunodeficiency in patients with hyper-immunoglobulin M (IgM) syndrome (HIGM1), and we demonstrate an intrinsic defect in the patients' B cells. Patients with HIGM1 have a defective CD40 ligand on their acti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Porat, Y B, Levy, D, Levy, J, Zan-Bar, I
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC170171/
https://ncbi.nlm.nih.gov/pubmed/7583916
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