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Somatic mutation of human immunoglobulin V genes in the X-linked HyperIgM syndrome.

Somatic mutation of Ig variable regions occurs prominently in germinal centers, but it has been debated whether the mutation process initiates in germinal centers or is activated before germinal center entry of B cells. We have analyzed for the presence of somatic mutation in Ig gene rearrangements...

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Detalhes bibliográficos
Main Authors: Chu, Y W, Marin, E, Fuleihan, R, Ramesh, N, Rosen, F S, Geha, R S, Insel, R A
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC441480/
https://ncbi.nlm.nih.gov/pubmed/7533792
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