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Ligation of high-melting-temperature ‘clamp’ sequence extends the scanning range of rare point-mutational analysis by constant denaturant capillary electrophoresis (CDCE) to most of the human genome

Mutations cause or influence the prevalence of many diseases. In human tissues, somatic point mutations have been observed at fractions at or below 4/10 000 and 5/100 000 in mitochondrial and nuclear DNA, respectively. In human populations, fractions for the multiple alleles that code for recessive...

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Sonraí Bibleagrafaíochta
Main Authors: Kim, Andrea S., Thilly, William G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2003
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC169989/
https://ncbi.nlm.nih.gov/pubmed/12907749
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