Fast and accurate determination of sites along the FUT2 in vitro transcript that are accessible to antisense oligonucleotides by application of secondary structure predictions and RNase H in combination with MALDI-TOF mass spectrometry

Alteration of gene expression by use of antisense oligonucleotides has considerable potential for therapeutic purposes and scientific studies. Although applied for almost 25 years, this technique is still associated with difficulties in finding antisense-effective regions along the target mRNA. This...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Gabler, Angelika, Krebs, Stefan, Seichter, Doris, Förster, Martin
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 2003
Assuntos:	NAR Methods Online
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC169965/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12888531/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gng079
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