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Intracellular mRNA cleavage by 3′ tRNase under the direction of 2′-O-methyl RNA heptamers

Mammalian tRNA 3′ processing endoribonuclease (3′-tRNase) can cleave any RNA at any site under the direction of small guide RNA (sgRNA) in vitro. sgRNAs can be as short as heptamers, which are much smaller than small interfering RNAs of ∼21 nt. Together with such flexibility in substrate recognition...

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Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Tamura, Masato, Nashimoto, Chikako, Miyake, Noriko, Daikuhara, Yasushi, Ochi, Kozo, Nashimoto, Masayuki
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2003
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC169917/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12888494/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg641
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