Intracellular mRNA cleavage by 3′ tRNase under the direction of 2′-O-methyl RNA heptamers

Mammalian tRNA 3′ processing endoribonuclease (3′-tRNase) can cleave any RNA at any site under the direction of small guide RNA (sgRNA) in vitro. sgRNAs can be as short as heptamers, which are much smaller than small interfering RNAs of ∼21 nt. Together with such flexibility in substrate recognition...

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Опубликовано в::	Nucleic Acids Res
Главные авторы:	Tamura, Masato, Nashimoto, Chikako, Miyake, Noriko, Daikuhara, Yasushi, Ochi, Kozo, Nashimoto, Masayuki
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Oxford University Press 2003
Предметы:	Articles
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC169917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12888494/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg641
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