Intracellular mRNA cleavage by 3′ tRNase under the direction of 2′-O-methyl RNA heptamers
Mammalian tRNA 3′ processing endoribonuclease (3′-tRNase) can cleave any RNA at any site under the direction of small guide RNA (sgRNA) in vitro. sgRNAs can be as short as heptamers, which are much smaller than small interfering RNAs of ∼21 nt. Together with such flexibility in substrate recognition...
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| Gepubliceerd in: | Nucleic Acids Res |
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| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2003
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC169917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12888494/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg641 |
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