Adaptive Stress Response in Segmental Progeria Resembles Long-Lived Dwarfism and Calorie Restriction in Mice

How congenital defects causing genome instability can result in the pleiotropic symptoms reminiscent of aging but in a segmental and accelerated fashion remains largely unknown. Most segmental progerias are associated with accelerated fibroblast senescence, suggesting that cellular senescence is a l...

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Main Authors: van de Ven, Marieke, Andressoo, Jaan-Olle, Holcomb, Valerie B, von Lindern, Marieke, Jong, Willeke M. C, Zeeuw, Chris I. De, Suh, Yousin, Hasty, Paul, Hoeijmakers, Jan H. J, van der Horst, Gijsbertus T. J, Mitchell, James R
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698946/
https://ncbi.nlm.nih.gov/pubmed/17173483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0020192
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