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The Gα12-RGS RhoGEF-RhoA signalling pathway regulates neurotransmitter release in C. elegans

In Caenorhabditis elegans adults, the single Rho GTPase orthologue, RHO-1, stimulates neurotransmitter release at synapses. We show that one of the pathways acting upstream of RHO-1 in acetylcholine (ACh)-releasing motor neurons depends on Gα12 (GPA-12), which acts via the single C. elegans RGS RhoG...

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Autori principali: Hiley, Emma, McMullan, Rachel, Nurrish, Stephen J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698903/
https://ncbi.nlm.nih.gov/pubmed/17139250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601458
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