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p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration

Internalization and proteolytic degradation of epidermal growth factor (EGF) receptor (R) following ligand binding is an important mechanism for regulating EGF-stimulated signals. Using pharmacological and RNA interference inhibition of p38 mitogen-activated protein kinase, we show that p38 is requi...

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Detalhes bibliográficos
Main Authors: Frey, Mark R, Dise, Rebecca S, Edelblum, Karen L, Polk, D Brent
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698902/
https://ncbi.nlm.nih.gov/pubmed/17139251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601457
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