p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration

Internalization and proteolytic degradation of epidermal growth factor (EGF) receptor (R) following ligand binding is an important mechanism for regulating EGF-stimulated signals. Using pharmacological and RNA interference inhibition of p38 mitogen-activated protein kinase, we show that p38 is requi...

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Bibliographic Details
Main Authors: Frey, Mark R, Dise, Rebecca S, Edelblum, Karen L, Polk, D Brent
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698902/
https://ncbi.nlm.nih.gov/pubmed/17139251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601457
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