Decreased Expression of Bmi1 Is Closely Associated with Cellular Senescence in Small Bile Ducts in Primary Biliary Cirrhosis

Cellular senescence of biliary epithelial cells with p16(INK4a) and p21(WAF1/Cip) expression in damaged small bile ducts may be critical for progressive bile duct loss in primary biliary cirrhosis. We investigated the involvement of bmi1, a polycomb group gene repressing p16(INK4a) expression, in th...

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Autores principales: Sasaki, Motoko, Ikeda, Hiroko, Sato, Yasunori, Nakanuma, Yasuni
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2006
Materias:
Regular Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698839/
https://ncbi.nlm.nih.gov/pubmed/16936260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051237
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