B-Lymphocyte Depletion Reduces Skin Fibrosis and Autoimmunity in the Tight-Skin Mouse Model for Systemic Sclerosis

Systemic sclerosis (scleroderma) is an autoimmune disease characterized by excessive extracellular matrix deposition in the skin. A direct role for B lymphocytes in disease development or progression has remained controversial, although autoantibody production is a feature of this disease. To addres...

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Autori principali: Hasegawa, Minoru, Hamaguchi, Yasuhito, Yanaba, Koichi, Bouaziz, Jean-David, Uchida, Junji, Fujimoto, Manabu, Matsushita, Takashi, Matsushita, Yukiyo, Horikawa, Mayuka, Komura, Kazuhiro, Takehara, Kazuhiko, Sato, Shinichi, Tedder, Thomas F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2006
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698806/
https://ncbi.nlm.nih.gov/pubmed/16936269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060205
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