B Lymphocyte Signaling Established by the CD19/CD22 Loop Regulates Autoimmunity in the Tight-Skin Mouse

Systemic sclerosis (SSc) is characterized by fibrosis and autoimmmunity. Peripheral blood B cells from SSc patients specifically overexpress CD19, a critical cell-surface signal transduction molecule in B cells. CD19 deficiency in B cells also attenuates skin fibrosis in the tight-skin (TSK/+) mouse...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Asano, Noriko, Fujimoto, Manabu, Yazawa, Norihito, Shirasawa, Senji, Hasegawa, Minoru, Okochi, Hitoshi, Tamaki, Kunihiko, Tedder, Thomas F., Sato, Shinichi
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2004
Sujets:
Regular Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618564/
https://ncbi.nlm.nih.gov/pubmed/15277237
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires