CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

The tight-skin (TSK/+) mouse, a genetic model for human systemic sclerosis (SSc), develops cutaneous fibrosis and autoantibodies against SSc-specific target autoantigens. Although molecular mechanisms explaining the development of fibrosis and autoimmunity in SSc patients or TSK/+ mice remain unknow...

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Autors principals: Saito, Eriko, Fujimoto, Manabu, Hasegawa, Minoru, Komura, Kazuhiro, Hamaguchi, Yasuhito, Kaburagi, Yuko, Nagaoka, Tetsuya, Takehara, Kazuhiko, Tedder, Thomas F., Sato, Shinichi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2002
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC150999/
https://ncbi.nlm.nih.gov/pubmed/12045259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI15078
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