B Lymphocyte Signaling Established by the CD19/CD22 Loop Regulates Autoimmunity in the Tight-Skin Mouse

Systemic sclerosis (SSc) is characterized by fibrosis and autoimmmunity. Peripheral blood B cells from SSc patients specifically overexpress CD19, a critical cell-surface signal transduction molecule in B cells. CD19 deficiency in B cells also attenuates skin fibrosis in the tight-skin (TSK/+) mouse...

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Main Authors: Asano, Noriko, Fujimoto, Manabu, Yazawa, Norihito, Shirasawa, Senji, Hasegawa, Minoru, Okochi, Hitoshi, Tamaki, Kunihiko, Tedder, Thomas F., Sato, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2004
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618564/
https://ncbi.nlm.nih.gov/pubmed/15277237
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