Mechanotransduction of Extracellular Signal-Regulated Kinases 1 and 2 Mitogen-Activated Protein Kinase Activity in Smooth Muscle Is Dependent on the Extracellular Matrix and Regulated by Matrix Metalloproteinases

Excessive wall stretch of distensible hollow organs in cardiovascular and urinary systems can activate matrix metalloproteinases (MMPs), thereby releasing matrix neoepitopes and growth factor ligands, leading to ERK1/2 activation. However, the role of MMPs in mechanotransduction of ERK1/2 signaling...

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Bibliographische Detailangaben
Hauptverfasser: Aitken, Karen J., Block, Gregory, Lorenzo, Armando, Herz, Daniel, Sabha, Nesrin, Dessouki, Omar, Fung, France, Szybowska, Marta, Craig, Laura, Bägli, Darius J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2006
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Regular Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698787/
https://ncbi.nlm.nih.gov/pubmed/16877348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050969
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