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Mechanotransduction of Extracellular Signal-Regulated Kinases 1 and 2 Mitogen-Activated Protein Kinase Activity in Smooth Muscle Is Dependent on the Extracellular Matrix and Regulated by Matrix Metalloproteinases

Excessive wall stretch of distensible hollow organs in cardiovascular and urinary systems can activate matrix metalloproteinases (MMPs), thereby releasing matrix neoepitopes and growth factor ligands, leading to ERK1/2 activation. However, the role of MMPs in mechanotransduction of ERK1/2 signaling...

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Detalhes bibliográficos
Main Authors: Aitken, Karen J., Block, Gregory, Lorenzo, Armando, Herz, Daniel, Sabha, Nesrin, Dessouki, Omar, Fung, France, Szybowska, Marta, Craig, Laura, Bägli, Darius J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698787/
https://ncbi.nlm.nih.gov/pubmed/16877348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050969
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