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Concurrent Expression of Hyaluronan Biosynthetic and Processing Enzymes Promotes Growth and Vascularization of Prostate Tumors in Mice
Aggressive cells in prostate cancer secrete extracellular hyaluronan (HA) as a result of up-regulated HA synthase enzymes HAS2 and HAS3. Combined detection of HA and the HA processing hyaluronidase enzyme Hyal1 in prostate tumors correlates with poor outcome. HA oligomers produced by hyaluronidases...
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Investigative Pathology
2006
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1698770/ https://ncbi.nlm.nih.gov/pubmed/16816377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060032 |
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