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Concurrent Expression of Hyaluronan Biosynthetic and Processing Enzymes Promotes Growth and Vascularization of Prostate Tumors in Mice

Aggressive cells in prostate cancer secrete extracellular hyaluronan (HA) as a result of up-regulated HA synthase enzymes HAS2 and HAS3. Combined detection of HA and the HA processing hyaluronidase enzyme Hyal1 in prostate tumors correlates with poor outcome. HA oligomers produced by hyaluronidases...

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Autor principal: Simpson, Melanie A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698770/
https://ncbi.nlm.nih.gov/pubmed/16816377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060032
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