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Disabled-2 Heterozygous Mice Are Predisposed to Endometrial and Ovarian Tumorigenesis and Exhibit Sex-Biased Embryonic Lethality in a p53-Null Background

Disabled-2 (Dab2) is a phosphoprotein involved in cellular signal transduction and endocytic trafficking. The expression of Dab2 is frequently lost or suppressed in several epithelial tumors, and studies of its cellular function and growth suppressive activity when re-expressed in cancer cells led t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yang, Dong-Hua, Fazili, Zia, Smith, Elizabeth R., Cai, Kathy Qi, Klein-Szanto, Andres, Cohen, Cynthia, Horowitz, Ira R., Xu, Xiang-Xi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698752/
https://ncbi.nlm.nih.gov/pubmed/16816378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060036
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