TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains

TopBP1 has eight BRCT [BRCA1 (breast-cancer susceptibility gene 1) C-terminus] domains and is involved in initiating DNA replication, and DNA damage checkpoint signalling and repair. Several BRCT-domain-containing proteins involved in mediating DNA repair have transcriptional regulatory domains, and...

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Bibliografiska uppgifter
Huvudupphovsmän: Wright, Roni H. G., Dornan, Edward S., Donaldson, Mary M., Morgan, Iain M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Portland Press Ltd. 2006
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698607/
https://ncbi.nlm.nih.gov/pubmed/16984230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060831
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