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TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains
TopBP1 has eight BRCT [BRCA1 (breast-cancer susceptibility gene 1) C-terminus] domains and is involved in initiating DNA replication, and DNA damage checkpoint signalling and repair. Several BRCT-domain-containing proteins involved in mediating DNA repair have transcriptional regulatory domains, and...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Portland Press Ltd.
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1698607/ https://ncbi.nlm.nih.gov/pubmed/16984230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060831 |
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