The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity

Dbl family GEFs (guanine nucleotide-exchange factors) for the Rho GTPases almost invariably contain a PH (pleckstrin homology) domain adjacent to their DH (Dbl homology) domain. The DH domain is responsible for GEF activity, and the PH domain plays a regulatory role that remains poorly understood. W...

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Bibliografiset tiedot
Päätekijät: Baumeister, Mark A., Rossman, Kent L., Sondek, John, Lemmon, Mark A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Portland Press Ltd. 2006
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698603/
https://ncbi.nlm.nih.gov/pubmed/17007612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061020
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