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The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity
Dbl family GEFs (guanine nucleotide-exchange factors) for the Rho GTPases almost invariably contain a PH (pleckstrin homology) domain adjacent to their DH (Dbl homology) domain. The DH domain is responsible for GEF activity, and the PH domain plays a regulatory role that remains poorly understood. W...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1698603/ https://ncbi.nlm.nih.gov/pubmed/17007612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061020 |
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