Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome

Cockayne syndrome (CS) is a photosensitive, DNA repair disorder associated with progeria that is caused by a defect in the transcription-coupled repair subpathway of nucleotide excision repair (NER). Here, complete inactivation of NER in Csb(m/m)/Xpa(−/−) mutants causes a phenotype that reliably mim...

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Hlavní autoři: van der Pluijm, Ingrid, Garinis, George A, Brandt, Renata M. C, Gorgels, Theo G. M. F, Wijnhoven, Susan W, Diderich, Karin E. M, de Wit, Jan, Mitchell, James R, van Oostrom, Conny, Beems, Rudolf, Niedernhofer, Laura J, Velasco, Susana, Friedberg, Errol C, Tanaka, Kiyoji, van Steeg, Harry, Hoeijmakers, Jan H. J, van der Horst, Gijsbertus T. J
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2007
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698505/
https://ncbi.nlm.nih.gov/pubmed/17326724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0050002
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