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SGTx1, a Kv Channel Gating-Modifier Toxin, Binds to the Interfacial Region of Lipid Bilayers

SGTx1 is a gating-modifier toxin that has been shown to inhibit the voltage-gated potassium channel Kv2.1. SGTx1 is thought to bind to the S3b-S4a region of the voltage-sensor, and is believed to alter the energetics of gating. Gating-modifier toxins such as SGTx1 are of interest as they can be used...

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Bibliografiske detaljer
Main Authors: Wee, Chze Ling, Bemporad, Daniele, Sands, Zara A., Gavaghan, David, Sansom, Mark S. P.
Format: Artigo
Sprog:Inglês
Udgivet: Biophysical Society 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1697838/
https://ncbi.nlm.nih.gov/pubmed/17071657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.098681
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