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From neuronal inclusions to neurodegeneration: neuropathological investigation of a transgenic mouse model of Huntington's disease
Huntington's disease (HD) is an inherited progressive neurodegenerative disease caused by the expansion of a polyglutamine repeat sequence within a novel protein. Recent work has shown that abnormal intranuclear inclusions of aggregated mutant protein within neurons is a characteristic feature...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1692612/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.1999.0448 |
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