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Interaction between Ski7p and Upf1p is required for nonsense-mediated 3′-to-5′ mRNA decay in yeast

Aberrant mRNAs containing premature termination codons (PTC-mRNAs) are degraded by a conserved surveillance system, referred to as the nonsense- mediated decay (NMD) pathway. Although NMD is reported to operate on the decapping and 5′-to-3′ exonucleolytic decay of PTC-mRNAs without affecting deadeny...

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Detalhes bibliográficos
Main Authors: Takahashi, Shinya, Araki, Yasuhiro, Sakuno, Takeshi, Katada, Toshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC169047/
https://ncbi.nlm.nih.gov/pubmed/12881429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg374
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