Site-directed ligand discovery

We report a strategy (called “tethering”) to discover low molecular weight ligands (≈250 Da) that bind weakly to targeted sites on proteins through an intermediary disulfide tether. A native or engineered cysteine in a protein is allowed to react reversibly with a small library of disulfide-containi...

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Xehetasun bibliografikoak
Egile Nagusiak: Erlanson, Daniel A., Braisted, Andrew C., Raphael, Darren R., Randal, Mike, Stroud, Robert M., Gordon, Eric M., Wells, James A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The National Academy of Sciences 2000
Gaiak:
Physical Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC16870/
https://ncbi.nlm.nih.gov/pubmed/10944209
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