The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-γ and lacking the SOCS-1 gene

Mice lacking the gene encoding the suppressor of cytokine signaling-1 (SOCS-1 −/−) and heterozygous for the IFN–γ gene (IFN-γ +/−) avoided the IFN-γ-dependent preweaning death of SOCS-1 −/− IFN-γ +/+ mice but did not exhibit the good health of young adult SOCS-1 −/− IFN-γ −/− mice. SOCS-1 −/− IFN-γ...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Metcalf, Donald, Di Rago, Ladina, Mifsud, Sandra, Hartley, Lynne, Alexander, Warren S.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16841/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908669/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.160255197
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