The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q

We have isolated the human GRAF gene (for GTPase regulator associated with the focal adhesion kinase pp125(FAK)). This gene was fused with MLL in a unique t(5;11)(q31;q23) that occurred in an infant with juvenile myelomonocytic leukemia. GRAF encodes a member of the Rho family of the GTPase-activati...

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Autors principals: Borkhardt, Arndt, Bojesen, Stig, Haas, Oskar A., Fuchs, Uta, Bartelheimer, Dominique, Loncarevic, Ivan F., Bohle, Rainer M., Harbott, Jochen, Repp, Reinald, Jaeger, Ulrich, Viehmann, Susanne, Henn, Traudl, Korth, Petra, Scharr, Dirk, Lampert, Fritz
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2000
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC16840/
https://ncbi.nlm.nih.gov/pubmed/10908648
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